We went 4-0 for +3.95 units last week, bringing our 2025 college lacrosse record to 19-13-1 for +6.85 units so far this season. We already bet Ohio State -1.5 at +104 on FanDuel earlier in the week and I have some more best bets for Week 6. Let’s take a look at the other four games that I’m targeting.
Note: The odds presented below are those at the time when Hutton sends his picks out to DubClub subscribers and are subject to change. Subscribe to Hutton Jackson’s lacrosse picks on DubClub so you never miss out on the best odds for these picks. As soon as Hutton places a bet, you’ll immediately get a notification with both the pick and brief analysis. Picks are sent out at least 20 minutes in advance of articles published on Bet On Lacrosse.
Loyola (Md) at Boston University
 Loyola (Md) Moneyline/Spread | +245 / +3.5 |
 Boston U Moneyline/Spread | -320 / -3.5 |
| Total | 20.5 |
| Time | Saturday · 12 p.m. ET |
| TV | ESPN+ |
Odds via FanDuel
Loyola and Boston University’s matchup is a prime example of why you should consider teams’ schedules when handicapping. The Greyhounds enter this game with an 0-6 record, but has played four ranked opponents—and nearly beat two of them. Meanwhile, none of the Terriers’ opponents so far are ranked and they’ve mostly beaten up on teams below their weight class.
When you look closer at the underlying metrics, these two teams are fairly even. Both teams have struggling offenses and above-average defenses. Boston ranks 54th in offensive efficiency and 20th in defensive efficiency excluding garbage time according to Lacrosse Reference. Loyola ranks 47th in offensive efficiency and 25th in defensive efficiency excluding garbage time. The faceoff battle between these two teams should also be fairly even.
Ultimately, this game should be closer to a pick ’em and you could even make a case that the wrong team is favored. Loyola is battle-tested with close losses to Maryland and Johns Hopkins and should come out hungry for their first win. Bet to win a unit on Loyola +3.5 at -122 and 0.4 unit on Loyola moneyline at +245 on FanDuel.
Picks: Loyola +2.5, Loyola ML (0.4 unit)
Duke at Richmond
 Duke Moneyline/Spread | -290 / -2.5 |
 Richmond Moneyline/Spread | +220 / +2.5 |
| Total | 24 |
| Time | Saturday · 12 p.m. ET |
| TV | ESPN+ |
Odds via Caesars
Richmond has been one of the best stories of the season so far and already has an upset over an ACC opponent this season. Meanwhile, Duke has been flying under-the-radar despite a 7-1 start, but they haven’t blown anyone out since their season-opening 26-7 win over Bellarmine.
Duke’s only loss was to Princeton and Richmond is closer in strength to the Tigers than they are to any of the Blue Devils other opponents. Duke currently ranks 13th in offensive efficiency and 31st in defensive efficiency excluding garbage time, while Richmond is 26th in offensive efficiency and 13th in defensive efficiency according to Lacrosse Reference. The Blue Devils could have a slight edge at the faceoff dot, but the Spiders have won games while getting beat handily at the draw and I expect this game to be lower-scoring, limiting any potential possession advantage for Duke.
Trust the Spiders to keep this game close and potentially even win outright. Bet Richmond +2.5 at -105 on DraftKings and a half unit on Richmond moneyline at +220 on Caesars.
Picks: Richmond +2.5, Richmond ML (0.5 unit)
Notre Dame at Michigan
 Notre Dame Moneyline/Spread | -850 / -4.5 |
 Michigan Moneyline/Spread | +540 / +4.5 |
| Total | 22.5 |
| Time | Saturday · 1 p.m. ET |
| TV | Big Ten Network |
Odds via FanDuel
Notre Dame is coming off consecutive losses for the first time since March 22, 2022, and has looked far from the dominant team we saw win back-to-back championships. Yet, the Irish lost to a pair of very good teams in Maryland and Ohio State.
The Terps and Buckeyes rank second and third in defensive efficiency this season, which explains why the Irish offense has stalled a bit recently. The Irish defense also played uncharacteristically poor against Maryland and Ohio State. The Irish gave up multiple transition goals to the Terps in that loss and their defense was sliding way too early in both of their losses, which unnecessarily created quality scoring chances for their Big Ten opponents. Starting goalie Thomas Ricciardelli also played particularly well against Ohio State, but the Buckeyes controlled possession and made the most of chances late in the shot clock.
Now, Notre Dame will face another really good Michigan defense that ranks eighth in defensive efficiency excluding garbage time, but has struggled against highly efficient offenses like North Carolina and Harvard. Notre Dame’s offense is still the second-most efficient behind only the Crimson. Notre Dame’s Will Lynch should also dominate at the faceoff dot and, if they get a better showing from their defense, the Irish could win by a sizeable margin on Saturday.
Expect the Irish to get back on track this weekend and bet Notre Dame -4.5 at -125 on Caesars or -128 on FanDuel.
Pick: Notre Dame -4.5
Jacksonville at North Carolina
 Jacksonville Moneyline/Spread | +1600 / +8.5 |
 North Carolina Moneyline/Spread | -5000 / -8.5 |
| Total | 23.5 |
| Time | Sunday · 2 p.m. ET |
| TV | ESPNU |
Odds via BetMGM
On Sunday, we’re treated to a matchup between the Dolphins and Tar Heels in Chapel Hill. This spread looks right to me, but I think the total of 23.5 is a few goals too low.
Both Jacksonville and North Carolina like to play fast, with the Dolphins ranking 6th fastest in offensive pace excluding garbage time and the Tar Heels ranking 28th according to Lacrosse Reference. While Jacksonville hasn’t been very efficient, ranking 40th, UNC currently boasts the third-most efficient offense in situations excluding garbage time.
Even if this game gets out of hand, North Carolina has shown a tendency to run up the score and their last four games have all gone over this mark. Expect a fast-paced game with plenty of scoring and bet Over 23.5 at -110 on BetMGM.
Pick: Over 23.5
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